OLSON RESEARCH GROUP
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Publications After 7/1/15
53. Vargas, M. V.; Dunlap, L. E.; Dong, C.; Carter, S. J.; Tombari, R. J.; Jami, S. A.; Cameron, L. P.; Patel, S. D.; Hennessey, J. J.; Saeger, H. N.; McCorvy, J. D.; Gray, J. A.; Tian, L.; Olson, D. E. Psychedelics Promote Neuroplasticity Through Activation of Intracellular 5-HT2A Receptors. Science, 2023, 379, 700–706.  Link.
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52. Tombari, R. J.; Mundy, P. C.; Morales, K. M.; Dunlap, L. E.; Olson, D. E.; Lein, P. J. Developmental Neurotoxicity Screen of Psychedelics and Other Drugs of Abuse in Larval Zebrafish (Danio rerio). ACS Chem. Neurosci., 2023, ASAP.  Link.
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51. Cameron, L. P.; Patel, S. D.; Vargas, M. V.; Barragan, E. V.; Saeger, H. N.; Warren, H. T.; Chow, W. L.; Gray, J. A.; Olson, D. E. 5-HT2ARs Mediate Therapeutic Behavioral Effects of Psychedelic Tryptamines. ACS Chem. Neurosci., 2023, ASAP.  Link.
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50. Grieco, S. F.; Castrén, E.; Knudsen, G. M.; Kwan, A. C.; Olson, D. E.; Zuo, Yi.; Holmes, T. C.; Xu, X. Psychedelics and Neural Plasticity: Therapeutic Implications. J. Neurosci., 2022, 42, 8439–8449. Link.
49. Ingelman-Sundberg, M.; Cadet, J. L.; Gobbi, G.; Olson, D. E.; Yohn, S.; Foster, D. J. Bridging the gap in neuropsychiatric translational research. Trends in Pharmacol. Sci., 2022. Link.
48. Kwan, A. C.; Olson, D. E.; Preller, K. H.; Rother, B. L. The Neural Basis of Psychedelic Action. Nat. Neurosci., 2022, https://doi.org/10.1038/s41593-022-01177-4. Link.
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47. ​Zhang, G.; Favela, D.; Chow, W.; Iyer, R. N.; Pell, A. J.; Olson, D. E. Synthesis of Tertiary Amines Through Extrusive Alkylation of Carbamates. Org. Lett., 2022, 24, 6208–6212. Link.
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46. ​Rasmussen, K.; Olson, D. E. Psychedelics as Standard of Care?  Many Questions Remain. Cam. Q. Healthc. Ethics., 2022, 31, 477–481. Link.
​45. Sutton, C.; Williams, E. Q.; Homsi, H.; Beerepoot, P.; Nazari, R.; Han, D.; Ramsey, A.; Mash, D. C.; Olson, D. E.; Blough, B. E.; Salahpour, A. Structure-Activity Relationships of Dopamine Transporter Pharmacological Chaperones, Front. Cell. Neurosci., 2022, 16, https://doi.org/10.3389/fncel.2022.832536.
44. Olson, D. E. Biochemical Mechanisms Underlying Psychedelic-Induced Neuroplasticity. Biochemistry, 2022, ASAP. Link.
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43. Patel, S. D.; Cameron, L. P.; Olson, D. E. Sex-Specific Social Effects on Depression-Related Behavioral Phenotypes in Mice. Life, 2021, 11, 1327. Link.
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42. Saeger, H. N.; Olson, D. E. Psychedelic-Inspired Approaches for Treating Neurodegenerative Disorders. J. Neurochem., 2021, DOI: 10.1111/JNC.15544. ​Link.
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41. Vargas, M. V.; Meyer, R.; Avanes, A.; Rus, M.; Olson, D. E. Psychedelics and Other Psychoplastogens for Treating Mental Illness. Front. Psychiatry, 2021, https://doi.org/10.3389/fpsyt.2021.727117. Link.
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40. Tombari, R. J.; Tuck, J. R.; Yardeny, N.; Gingrich, P. W.; Tantillo, D. J.; Olson, D. E. Calculated Oxidation Potentials Predict Reactivity in Baeyer-Mills Reactions. Org. Biomol. Chem., 2021, DOI: 10.1039/d1ob01450a.  Link.
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39. Cameron, L. P.; Olson, D. E. The Evolution of the Psychedelic Revolution. Neuropsychopharmacology, 2021, https://doi.org/10.1038/s41386-021-01150-y. Link.
38. Peters, J.; Olson, D. E. Engineering Safer Psychedelics for Treating Addiction. Neuroscience Insights, 2021, 16, https://doi.org/10.1177/26331055211033847. Link.
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37. Lu, Ju.; Tjia, M.; Mullen, B.; Cao, B.; Łukasiewicz, K.; Shah-Morales, S.; Weiser, S.; Cameron, L. P.; Olson, D. E.; Chen, L.; Zuo, Y. An Analog of Psychedelics Restores Functional Neural Circuits Disrupted by Unpredictable Stress. Mol. Psychiatry, 2021, Link.
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36. Tuck, J. R.; Tombari, R. J.; Yardeny, N.; Olson, D. E. A Modular Approach to Arylazo-1,2,3-triazole Photoswitches. Org. Lett., 2021, 23, 4305–4310. Link
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35. Dong, C.; Ly, C.; Dunlap, L. E.; Vargas, M. V.; Sun, J.; Hwang, I.-W.; Azinfar, A.; Oh, W. C.; Wetsel, W. C.; Olson, D. E.; Tian, L. Psychedelic-Inspired Drug Discovery Using an Engineered Biosensor. Cell, 2021, 10, 2779-2792.e18. Link
​​Covered By:
Academic Times
Nature

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Benzinga
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34. Olson, D. E. The Promise of Psychedelic Science. ACS Pharmacol. Transl. Sci., 2021, 4, 413–415 Link.
33. Unger, E. K.; Keller, J. P.; Altermatt, M.; Liang, R.; Yao, Z.; Sun, J.; Matsui, A.; Dong, C. E.; Hon, O. J.; Yao, Z.; Sun, J.; Banala, S.; Flanigan, M. E.; Jaffe, D. A.; Hartanto, S.; Carlen, J.; Mizuno, G. O.; Borden, P. M.; Shivange, A. V.; Cameron, L. P.; Sinning, S.; Underhill, S. M.; Olson, D. E.; Amara, S. G.; Lang, D. T.; Rudnick, G.; Marvin, J.; Lavis, L. D.; Lester, H. A.; Alvarez, V. A.; Fisher, A. J.; Prescher, J. A.; Kash, T. L.; Yarov-Yarovoy, V.; Gradinaru, V.; Looger, L. L.; Tian, L. Directed Evolution of a Selective and Sensitive Serotonin Sensor Via Machine Learning. Cell, 2020, 183, 1986–2002.e26.  Link.
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32. Olson, D. E. The Subjective Effects of Psychedelics May Not Be Necessary for Their Enduring Therapeutic Effects. ACS Pharmacol. Transl. Sci., 2020, 4, 563–567 Link.
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31. Cameron, L. P.; Tombari, R. J.; Lu, J.; Pell, A. J.; Hurley, Z. Q.; Ehinger, Y.; Vargas, M. V.; McCarroll, M. N.; Taylor, J. C.; Myers-Turnbull, D.; Liu, T.; Yaghoobi, B.; Laskowski, L. J.; Anderson, E. I.; Zhang, G.; Viswanathan, J.; Brown, B. M.; Tjia, M.; Dunlap, L. E.; Rabow, Z. T.; Fiehn, O.; Wulff, H.; McCorvy,  J. D.; Lein, P. J.; Kokel, D.; Ron, D.; Peters, J.; Zuo, Y.; Olson, D. E. A Non-Hallucinogenic Psychedelic Analogue with Therapeutic Potential. Nature, 2021, 589, 474–479.  Link
​​Covered By:
​Nature
Science
​C&E News
NPR
​Nature Reviews Drug Discovery

​Chemistry World
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Sacramento Business Journal
Medical News Today
Time
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30. Ly, C.; Greb, C. A.; Vargas, M. V.; Duim, W. C.; Grodzki, A. C. G.; Lein, P. J.; Olson, D. E. Transient Stimulation with Psychoplastogens is Sufficient to Initiate Neuronal Growth. ACS Pharmacol. Transl. Sci., 2020, 4, 452–460. Link
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29. Iyer, R. N.; Favela, D.; Zhang, G.; Olson, D. E. The Iboga Enigma: The Chemistry and Neuropharmacology of Iboga Alkaloids and Related Analogs. Nat. Prod. Rep., 2020, 38, 307–329. Link
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28. Ly, C.; Shimizu, A. J.; Vargas, M. V.; Duim, W. C.; Wender, P. A.; Olson, D. E. Bryostatin 1 Promotes Synaptogenesis and Reduces Dendritic Spine Density in Cortical Cultures Through a PKC-Dependent Mechanism. ACS Chem. Neurosci., 2020, 11, 1545–1554. Link
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27. Cameron, L. P.; Nazarian, A.; Olson, D. E. Psychedelic Microdosing: Prevalence and Subjective Effects. J. Psychoactive Drugs, 2020, 52, 113–122. Link​​
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26. Dunlap, L. E.; Azinfar, A.; Ly, C.; Cameron, L. P.; Viswanathan, J.; Tombari, R. J.; Myers-Turnbull, D.; Taylor, J. C.; Grodzki, A. C.; Lein, P. J.; Kokel, D.; Olson, D. E. Identification of Psychoplastogenic N,N-Dimethylaminoisotryptamine (isoDMT) Analogs Through Structure-Activity Relationship Studies. J. Med. Chem., 2020, 63, 1142–1155. Link​​
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25. Tsui, K. Y.; Tombari, R. J.; Olson, D. E.; Tantillo, D. J. Reconsidering the Structure of Serlyticin-A. J. Nat. Prod., 2019, 82, 3464-3468. Link​
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24. Zhu, J. S.; Larach, J. M.; Tombari, R. J.; Gingrich, P. W.; Bode, S. R.; Tuck, J. R.; Warren, H. T.; Son, J.-H.; Duim, W. C.; Fettinger, J. C.; Haddadin, M. J.; Tantillo, D. J.; Kurth, M. J.; Olson, D. E. "A Redox Isomerization Strategy for Accessing Modular Azobenzene Photoswitches with Near Quantitative Bidirectional Photoconversion." Org. Lett. 2019, 21, 8765-8770. Link
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23. Tombari, R. J.; Saunders, C. M.; Wu, C.-Y.; Dunlap, L. E.; Tantillo, D. J.; Olson, D. E. "Ex Vivo Analysis of Tryptophan Metabolism Using 19F NMR." ACS Chem. Biol. 2019, 14, 1866-1873. Link
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22. Cameron, L. P.; Benson, C. J.; DeFelice, B. C.; Fiehn, O.; Olson, D. E. "Chronic, Intermittent Microdoses of the Psychedelic N,N‐Dimethyltryptamine (DMT) Produce Positive Effects on Mood and Anxiety in Rodents." ACS Chem. Neurosci., 2019, 10, 3261−3270. Link
​​Selected as ACS Editors' Choice
Covered By:
Inverse

​The Atlantic
Psychology Today
​Science Daily
​Neuroscience News
Capital Public Radio
Knowable Magazine
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GQ


Medical Express
Motherboard
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​Insider
​The Scientist
​Esquire

Your Tango
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21. Kearney, S. E.; et al. "Canvass: A Crowd-Sourced Natural-Product Screening Library for Exploring Biological Space." ACS Cent. Sci., 2018, 4, 1727–1741. Link
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20. Olson, D. E. "Psychoplastogens: A Promising Class of Plasticity-Promoting Neurotherapeutics" J. of Exp. Neurosci. 2018, 12, 1–4. https://doi.org/10.1177/1179069518800508. Link
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19. Cameron, L. P.; Olson, D. E. "Dark Classics in Chemical Neuroscience: N,N-Dimethyltryptamine (DMT)" ACS Chem. Neurosci. 2018, 9, 2344–2357. Link
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18. Dunlap, L. E.; Andrews, A. A.; Olson, D. E. "Dark Classics in Chemical Neuroscience: 3,4-Methylenedioxymethamphetamine" ACS Chem. Neurosci. 2018, 9, 2408–2427. Link
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17. Ly, C.; Greb, A. C.; Cameron, L. P.; Wong, J. M.; Barragan, E. V.; Wilson, P. C.; Burbach, K. F.; Soltanzadeh Zarandi, S.; Sood, A.; Paddy, M. R.; Duim, W. C.; Dennis, M. Y.; McAllister, A. K.; Ori-McKenney, K. M.; Gray, J. A.; Olson, D. E. "Psychedelics Promote Structural and Functional Neural Plasticity" Cell Reports 2018, 23, 3170–3182. Link
Recommended by F1000Prime as being of special significance to the field 
Voted one of the top 16 biomedical research discoveries of the year as part of STAT Madness
​Covered By:
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LiveScience
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Tech Times
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Davis Enterprise
Dateline UC Davis
​UC Davis
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On TV or Radio:
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16. Dunlap, L. E.; Olson, D. E. Reaction of N,N-Dimethyltryptamine with Dichloromethane Under Common Experimental Conditions" ACS Omega 2018, 3, 4968–4973. Link
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15. Su, J. Y.; Olson, D. E.; Ting, S. I.; Du Bois, J. "Synthetic Studies Toward Pactamycin Highlighting Oxidative C–H and Alkene Amination Technologies" J. Org. Chem. 2018, 83, 7121–7134. Link
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14. Cameron, L. P.; Benson, C. J.; Dunlap, L. E.; Olson, D. E. Effects of N,N-dimethyltryptamine (DMT) on rat behaviors relevant to anxiety and depression" ACS Chem. Neurosci. 2018, 9, 1582–1590. Link
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13. Wagner, F. F.; Bishop, J. A; Gale, J. P.; Shi, X.; Walk, M.; Ketterman, J.; Patnaik, D.; Barker, D.; Walpita, D.; Campbell, A. J.; Nguyen, S.; Lewis, M.; Ross, L.; Weiwer, M.; An, F.; Germain, A. R.; Nag, P. P.; Metkar, S.; Kaya, T.; Dandapani, S.; Olson, D. E.; Barbe, A.-L.; Lazarro, F.; Sacher, J. R.; Cheah, J. H.; Fei, D.; Perez, J. R.; Munoz, B.; Palmer, M.; Stegmaier, K.; Schreiber, S. L.; Scolnick, E.; Zhang, Y.-L.; Haggarty, S. J.; Holson, E. B.; Pan, J. Q. “Inhibitors of Glycogen Synthase Kinase 3 with Exquisite Kinome-wide Selectivity and their Functional Effects” ACS Chem. Bio. 2016, 11, 1952–1963. Link
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12. Dirice, E.; Walpita, D.; Vetere, A.; Meier, B. C.; Kahraman, S.; Hu, J.; Dancik, V.; Burns, S. M.; Gilbert, T. J.; Olson, D. E.; Clemons, P. A.; Kulkami, R. N.; Wagner, B. K. “Inhibition of DYRK1A Stimulates Human Beta-cell Proliferation” Diabetes 2016, 65, 1660–1671.​ Link

Publications Before 7/1/15
11. Olson, D. E.; Sleiman, S. F.; Bourassa, M. W.; Wagner, F. F.; Gale, J. P.; Zhang, Y.-L.; Ratan, R. R.; Holson, E. B. “Hydroxamate-based Histone Deacetylase Inhibitors Can Protect Neurons from Oxidative Stress by Forming Catalase Mimetic Complexes with Intracellular Iron” Cell Chem. Biol. (formerly Chem. Biol.) 2015, 22, 439-445. Link
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Highlighted In Chemistry & Biology: Tackling Oxidative Stress by a Direct Route: A New Job for HDAC Inhibitors?

10. Olson, D. E., Udeshi, N.; Wolfson, N. A.; Pitcairn, C. A.; Sullivan, E. D.; Jaffe, J.; Svinkina, T.; Natoli, T.; Liu, X.; Paulk, J.; McCarren, P.; Wagner, F. F.; Barker, D.; Howe, E.; Lazzaro, F.; Gale, J. P.; Zhang, Y.-L.; Subramanian, A.; Fierke, C.; Carr, S.; Holson, E. B. “An Unbiased Approach to Identify Endogenous Substrates of “Histone” Deacetylase 8” ACS Chem. Bio. 2014, 9, 2210-2216. Link
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9. Sleiman, S. F.; Olson, D. E.; Bourassa, M. W.; Karuppagounder, S. S.; Zhang, Y.-L.; Gale, J.; Wagner, F. F.; Basso, M.; Coppola, G.; Pinto, J. T.; Holson, E. B.; Ratan, R. R. “Hydroxamic Acid-based Histone Deacetylase (HDAC) Inhibitors Can Mediate Neuroprotection Independent of HDAC Inhibition” J. Neurosci. 2014, 34, 14328-14337. Link
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8. Olson, D. E.; Su, J. Y.; Roberts, D. A.; Du Bois, J. “Vicinal Diamination of Alkenes under Rh-Catalysis” J. Am. Chem. Soc. 2014, 136, 13506-13509. Link
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7. Olson, D. E.; Wagner, F. F.; Kaya, T.; Gale, J; Aidoud, N.; Davoine, E. L.; Lazzaro, F.; Weïwer, M.; Zhang, Y.-L.; Holson, E. B. “Discovery of the First Histone Deacetylase 6/8 Dual Inhibitors” J. Med. Chem. 2013, 56, 4816-4820. Link
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6. Wagner F. F.; Olson D. E.;  Gale J. P.; Kaya T.; Weïwer M.; Aidoud N.; Thomas M.; Davoine E. L.; Lemercier B. C.; Zhang Y.-L.; Holson E. B. “Potent and Selective Inhibition of Histone Deacetylase 6 (HDAC6) Does Not Require a Surface-binding Motif” J. Med. Chem. 2013, 56, 1772-1776. Link
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5. Olson, D. E.; Roberts, D. A.; Du Bois, J. “Synthesis of Differentially-substituted 1,2-Diamines through Advances in C–H Amination Technology” Org. Lett. 2012, 14, 6174-6177. Link
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4. Olson, D. E.; Maruniak, A.; Malhotra, S.; Trost, B. M.; Du Bois, J. “Synthesis and Reactivity of Unique Heterocyclic Structures en route to Substituted Diamines” Org. Lett. 2011, 13, 336-339. Link
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3. Olson, D. E. “Electrophilic Amination of Organometallic Reagents: Recent Discoveries and Mechanistic Insights” Mini-Rev. Org. Chem. 2011, 8, 341-346. Link
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2. Trost, B. M.; Malhotra, S.; Olson, D. E.; Maruniak, A.; Du Bois, J. “Asymmetric Synthesis of Diamine Derivatives via Sequential Palladium and Rhodium Catalysis” J. Am. Chem. Soc. 2009, 131, 4190-4191. Link
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1. Olson, D. E.; Du Bois, J. “Catalytic C–H Amination for the Preparation of Substituted 1,2-Diamines” J. Am. Chem. Soc. 2008, 130, 11248-11249. Link
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