Publications After 7/1/15
64. Muir, J.; Lin, S.; Aarrestad, I. K.; Daniels, H. R.; Ma, J.; Tian, L.; Olson, D. E.; Kim, C. K. Isolation of psychedelic-responsive neurons underlying anxiolytic behavioral states. Science, 2024, 386, 802–810. Link.
63. Bonilla, J.; Giannotti, G.; Kregar, N. P.; Heinsbroek, J. A.; Olson, D. E.; Peters, J. The psychedelic drug DOI reduces heroin motivation by targeting 5-HT2A receptors in a heroin and alcohol co-use model. Neuropharmacology, 2024, online ahead of print. https://doi.org/10.1016/j.neuropharm.2024.110163
62. Zhang, R.; Anguiano, M.; Aarrestad, I. K.; Lin, S.; Chandra, J.; Vadde, S. S.; Olson, D. E.; Kim, C. K. Rapid, biochemical tagging of cellular activity history in vivo. Nat. Methods, 2024, doi: 10.1038/s41592-024-02375-7. Link.
61. Warren, H. T.; Chow, W. L.; Chytil, M.; Rasmussen, K.; Olson, D. E. Identification of Psychoplastogenic Tropanes Lacking Muscarinic Activity. J. Med. Chem., 2024, 67, 12410–12427. Link.
60. Warren, H. T.; Saeger, H. N.; Tombari, R. J.; Chytil, M.; Rasmussen, K.; Olson, D. E. Psychoplastogenic DYRK1A Inhibitors with Therapeutic Effects Relevant to Alzheimer’s Disease. J. Med. Chem., 2024, 67, 6922–6937. Link.
59. Hatzipantelis, C. J.; Olson, D. E. The Effects of Psychedelics on Neuronal Physiology. Annu. Rev. Physiol., 2023, Link.
58. Chow, W. L.; Gonzalez, M. A.; Avanes, A. A.; Olson, D. E. Rapid Synthesis of Psychoplastogenic Tropane Alkaloids. JACS Au, 2023, Link.
57. Tuck, J. R.; Dunlap, L. E.; Olson, D. E. Synthetic Strategies toward Lysergic Acid Diethylamide: Ergoline Synthesis via α-Arylation, Borrowing Hydrogen Alkylation, and C–H Insertion, J. Org. Chem., 2023, Link.
56. Wallace, R.; Olson, D. E.; Hooker, J. Neuroplasticity: The Continuum of Change, ACS Chem. Neurosci., 2023, Link.
55. Heifets, B. D.; Olson, D. E. Therapeutic Mechanisms of Psychedelics and Entactogens. Neuropsychopharmacology, 2023, ASAP. Link.
54. Heinsbroek, J. A.; Giannotti, Giuseppe; Bonilla, J.; Olson, D. E.; Peters, J. Tabernanthalog Reduces Motivation for Heroin and Alcohol in a Polydrug Use Model. Psychedelic Medicine, 2023, ASAP. Link.
53. Vargas, M. V.; Dunlap, L. E.; Dong, C.; Carter, S. J.; Tombari, R. J.; Jami, S. A.; Cameron, L. P.; Patel, S. D.; Hennessey, J. J.; Saeger, H. N.; McCorvy, J. D.; Gray, J. A.; Tian, L.; Olson, D. E. Psychedelics Promote Neuroplasticity Through Activation of Intracellular 5-HT2A Receptors. Science, 2023, 379, 700–706. Link.
52. Tombari, R. J.; Mundy, P. C.; Morales, K. M.; Dunlap, L. E.; Olson, D. E.; Lein, P. J. Developmental Neurotoxicity Screen of Psychedelics and Other Drugs of Abuse in Larval Zebrafish (Danio rerio). ACS Chem. Neurosci., 2023, ASAP. Link.
51. Cameron, L. P.; Patel, S. D.; Vargas, M. V.; Barragan, E. V.; Saeger, H. N.; Warren, H. T.; Chow, W. L.; Gray, J. A.; Olson, D. E. 5-HT2ARs Mediate Therapeutic Behavioral Effects of Psychedelic Tryptamines. ACS Chem. Neurosci., 2023, 14, 351–358. Link.
50. Grieco, S. F.; Castrén, E.; Knudsen, G. M.; Kwan, A. C.; Olson, D. E.; Zuo, Yi.; Holmes, T. C.; Xu, X. Psychedelics and Neural Plasticity: Therapeutic Implications. J. Neurosci., 2022, 42, 8439–8449. Link.
49. Ingelman-Sundberg, M.; Cadet, J. L.; Gobbi, G.; Olson, D. E.; Yohn, S.; Foster, D. J. Bridging the gap in neuropsychiatric translational research. Trends in Pharmacol. Sci., 2022. Link.
48. Kwan, A. C.; Olson, D. E.; Preller, K. H.; Roth, B. L. The Neural Basis of Psychedelic Action. Nat. Neurosci., 2022, https://doi.org/10.1038/s41593-022-01177-4. Link.
47. Zhang, G.; Favela, D.; Chow, W.; Iyer, R. N.; Pell, A. J.; Olson, D. E. Synthesis of Tertiary Amines Through Extrusive Alkylation of Carbamates. Org. Lett., 2022, 24, 6208–6212. Link.
46. Rasmussen, K.; Olson, D. E. Psychedelics as Standard of Care? Many Questions Remain. Cam. Q. Healthc. Ethics., 2022, 31, 477–481. Link.
45. Sutton, C.; Williams, E. Q.; Homsi, H.; Beerepoot, P.; Nazari, R.; Han, D.; Ramsey, A.; Mash, D. C.; Olson, D. E.; Blough, B. E.; Salahpour, A. Structure-Activity Relationships of Dopamine Transporter Pharmacological Chaperones, Front. Cell. Neurosci., 2022, 16, https://doi.org/10.3389/fncel.2022.832536.
44. Olson, D. E. Biochemical Mechanisms Underlying Psychedelic-Induced Neuroplasticity. Biochemistry, 2022, 61, 127–136. Link.
43. Patel, S. D.; Cameron, L. P.; Olson, D. E. Sex-Specific Social Effects on Depression-Related Behavioral Phenotypes in Mice. Life, 2021, 11, 1327. Link.
42. Saeger, H. N.; Olson, D. E. Psychedelic-Inspired Approaches for Treating Neurodegenerative Disorders. J. Neurochem., 2021, DOI: 10.1111/JNC.15544. Link.
41. Vargas, M. V.; Meyer, R.; Avanes, A.; Rus, M.; Olson, D. E. Psychedelics and Other Psychoplastogens for Treating Mental Illness. Front. Psychiatry, 2021, https://doi.org/10.3389/fpsyt.2021.727117. Link.
40. Tombari, R. J.; Tuck, J. R.; Yardeny, N.; Gingrich, P. W.; Tantillo, D. J.; Olson, D. E. Calculated Oxidation Potentials Predict Reactivity in Baeyer-Mills Reactions. Org. Biomol. Chem., 2021, DOI: 10.1039/d1ob01450a. Link.
39. Cameron, L. P.; Olson, D. E. The Evolution of the Psychedelic Revolution. Neuropsychopharmacology, 2021, https://doi.org/10.1038/s41386-021-01150-y. Link.
38. Peters, J.; Olson, D. E. Engineering Safer Psychedelics for Treating Addiction. Neuroscience Insights, 2021, 16, https://doi.org/10.1177/26331055211033847. Link.
37. Lu, Ju.; Tjia, M.; Mullen, B.; Cao, B.; Łukasiewicz, K.; Shah-Morales, S.; Weiser, S.; Cameron, L. P.; Olson, D. E.; Chen, L.; Zuo, Y. An Analog of Psychedelics Restores Functional Neural Circuits Disrupted by Unpredictable Stress. Mol. Psychiatry, 2021, Link.
36. Tuck, J. R.; Tombari, R. J.; Yardeny, N.; Olson, D. E. A Modular Approach to Arylazo-1,2,3-triazole Photoswitches. Org. Lett., 2021, 23, 4305–4310. Link
35. Dong, C.; Ly, C.; Dunlap, L. E.; Vargas, M. V.; Sun, J.; Hwang, I.-W.; Azinfar, A.; Oh, W. C.; Wetsel, W. C.; Olson, D. E.; Tian, L. Psychedelic-Inspired Drug Discovery Using an Engineered Biosensor. Cell, 2021, 10, 2779-2792.e18. Link
34. Olson, D. E. The Promise of Psychedelic Science. ACS Pharmacol. Transl. Sci., 2021, 4, 413–415 Link.
33. Unger, E. K.; Keller, J. P.; Altermatt, M.; Liang, R.; Yao, Z.; Sun, J.; Matsui, A.; Dong, C. E.; Hon, O. J.; Yao, Z.; Sun, J.; Banala, S.; Flanigan, M. E.; Jaffe, D. A.; Hartanto, S.; Carlen, J.; Mizuno, G. O.; Borden, P. M.; Shivange, A. V.; Cameron, L. P.; Sinning, S.; Underhill, S. M.; Olson, D. E.; Amara, S. G.; Lang, D. T.; Rudnick, G.; Marvin, J.; Lavis, L. D.; Lester, H. A.; Alvarez, V. A.; Fisher, A. J.; Prescher, J. A.; Kash, T. L.; Yarov-Yarovoy, V.; Gradinaru, V.; Looger, L. L.; Tian, L. Directed Evolution of a Selective and Sensitive Serotonin Sensor Via Machine Learning. Cell, 2020, 183, 1986–2002.e26. Link.
32. Olson, D. E. The Subjective Effects of Psychedelics May Not Be Necessary for Their Enduring Therapeutic Effects. ACS Pharmacol. Transl. Sci., 2020, 4, 563–567 Link.
31. Cameron, L. P.; Tombari, R. J.; Lu, J.; Pell, A. J.; Hurley, Z. Q.; Ehinger, Y.; Vargas, M. V.; McCarroll, M. N.; Taylor, J. C.; Myers-Turnbull, D.; Liu, T.; Yaghoobi, B.; Laskowski, L. J.; Anderson, E. I.; Zhang, G.; Viswanathan, J.; Brown, B. M.; Tjia, M.; Dunlap, L. E.; Rabow, Z. T.; Fiehn, O.; Wulff, H.; McCorvy, J. D.; Lein, P. J.; Kokel, D.; Ron, D.; Peters, J.; Zuo, Y.; Olson, D. E. A Non-Hallucinogenic Psychedelic Analogue with Therapeutic Potential. Nature, 2021, 589, 474–479. Link
30. Ly, C.; Greb, C. A.; Vargas, M. V.; Duim, W. C.; Grodzki, A. C. G.; Lein, P. J.; Olson, D. E. Transient Stimulation with Psychoplastogens is Sufficient to Initiate Neuronal Growth. ACS Pharmacol. Transl. Sci., 2020, 4, 452–460. Link
29. Iyer, R. N.; Favela, D.; Zhang, G.; Olson, D. E. The Iboga Enigma: The Chemistry and Neuropharmacology of Iboga Alkaloids and Related Analogs. Nat. Prod. Rep., 2020, 38, 307–329. Link
28. Ly, C.; Shimizu, A. J.; Vargas, M. V.; Duim, W. C.; Wender, P. A.; Olson, D. E. Bryostatin 1 Promotes Synaptogenesis and Reduces Dendritic Spine Density in Cortical Cultures Through a PKC-Dependent Mechanism. ACS Chem. Neurosci., 2020, 11, 1545–1554. Link
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27. Cameron, L. P.; Nazarian, A.; Olson, D. E. Psychedelic Microdosing: Prevalence and Subjective Effects. J. Psychoactive Drugs, 2020, 52, 113–122. Link
26. Dunlap, L. E.; Azinfar, A.; Ly, C.; Cameron, L. P.; Viswanathan, J.; Tombari, R. J.; Myers-Turnbull, D.; Taylor, J. C.; Grodzki, A. C.; Lein, P. J.; Kokel, D.; Olson, D. E. Identification of Psychoplastogenic N,N-Dimethylaminoisotryptamine (isoDMT) Analogs Through Structure-Activity Relationship Studies. J. Med. Chem., 2020, 63, 1142–1155. Link
25. Tsui, K. Y.; Tombari, R. J.; Olson, D. E.; Tantillo, D. J. Reconsidering the Structure of Serlyticin-A. J. Nat. Prod., 2019, 82, 3464-3468. Link
24. Zhu, J. S.; Larach, J. M.; Tombari, R. J.; Gingrich, P. W.; Bode, S. R.; Tuck, J. R.; Warren, H. T.; Son, J.-H.; Duim, W. C.; Fettinger, J. C.; Haddadin, M. J.; Tantillo, D. J.; Kurth, M. J.; Olson, D. E. "A Redox Isomerization Strategy for Accessing Modular Azobenzene Photoswitches with Near Quantitative Bidirectional Photoconversion." Org. Lett. 2019, 21, 8765-8770. Link
23. Tombari, R. J.; Saunders, C. M.; Wu, C.-Y.; Dunlap, L. E.; Tantillo, D. J.; Olson, D. E. "Ex Vivo Analysis of Tryptophan Metabolism Using 19F NMR." ACS Chem. Biol. 2019, 14, 1866-1873. Link
22. Cameron, L. P.; Benson, C. J.; DeFelice, B. C.; Fiehn, O.; Olson, D. E. "Chronic, Intermittent Microdoses of the Psychedelic N,N‐Dimethyltryptamine (DMT) Produce Positive Effects on Mood and Anxiety in Rodents." ACS Chem. Neurosci., 2019, 10, 3261−3270. Link
21. Kearney, S. E.; et al. "Canvass: A Crowd-Sourced Natural-Product Screening Library for Exploring Biological Space." ACS Cent. Sci., 2018, 4, 1727–1741. Link
20. Olson, D. E. "Psychoplastogens: A Promising Class of Plasticity-Promoting Neurotherapeutics" J. of Exp. Neurosci. 2018, 12, 1–4. https://doi.org/10.1177/1179069518800508. Link
19. Cameron, L. P.; Olson, D. E. "Dark Classics in Chemical Neuroscience: N,N-Dimethyltryptamine (DMT)" ACS Chem. Neurosci. 2018, 9, 2344–2357. Link
18. Dunlap, L. E.; Andrews, A. A.; Olson, D. E. "Dark Classics in Chemical Neuroscience: 3,4-Methylenedioxymethamphetamine" ACS Chem. Neurosci. 2018, 9, 2408–2427. Link
17. Ly, C.; Greb, A. C.; Cameron, L. P.; Wong, J. M.; Barragan, E. V.; Wilson, P. C.; Burbach, K. F.; Soltanzadeh Zarandi, S.; Sood, A.; Paddy, M. R.; Duim, W. C.; Dennis, M. Y.; McAllister, A. K.; Ori-McKenney, K. M.; Gray, J. A.; Olson, D. E. "Psychedelics Promote Structural and Functional Neural Plasticity" Cell Reports 2018, 23, 3170–3182. Link
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16. Dunlap, L. E.; Olson, D. E. Reaction of N,N-Dimethyltryptamine with Dichloromethane Under Common Experimental Conditions" ACS Omega 2018, 3, 4968–4973. Link
15. Su, J. Y.; Olson, D. E.; Ting, S. I.; Du Bois, J. "Synthetic Studies Toward Pactamycin Highlighting Oxidative C–H and Alkene Amination Technologies" J. Org. Chem. 2018, 83, 7121–7134. Link
14. Cameron, L. P.; Benson, C. J.; Dunlap, L. E.; Olson, D. E. Effects of N,N-dimethyltryptamine (DMT) on rat behaviors relevant to anxiety and depression" ACS Chem. Neurosci. 2018, 9, 1582–1590. Link
13. Wagner, F. F.; Bishop, J. A; Gale, J. P.; Shi, X.; Walk, M.; Ketterman, J.; Patnaik, D.; Barker, D.; Walpita, D.; Campbell, A. J.; Nguyen, S.; Lewis, M.; Ross, L.; Weiwer, M.; An, F.; Germain, A. R.; Nag, P. P.; Metkar, S.; Kaya, T.; Dandapani, S.; Olson, D. E.; Barbe, A.-L.; Lazarro, F.; Sacher, J. R.; Cheah, J. H.; Fei, D.; Perez, J. R.; Munoz, B.; Palmer, M.; Stegmaier, K.; Schreiber, S. L.; Scolnick, E.; Zhang, Y.-L.; Haggarty, S. J.; Holson, E. B.; Pan, J. Q. “Inhibitors of Glycogen Synthase Kinase 3 with Exquisite Kinome-wide Selectivity and their Functional Effects” ACS Chem. Bio. 2016, 11, 1952–1963. Link
12. Dirice, E.; Walpita, D.; Vetere, A.; Meier, B. C.; Kahraman, S.; Hu, J.; Dancik, V.; Burns, S. M.; Gilbert, T. J.; Olson, D. E.; Clemons, P. A.; Kulkami, R. N.; Wagner, B. K. “Inhibition of DYRK1A Stimulates Human Beta-cell Proliferation” Diabetes 2016, 65, 1660–1671. Link
Publications Before 7/1/15
11. Olson, D. E.; Sleiman, S. F.; Bourassa, M. W.; Wagner, F. F.; Gale, J. P.; Zhang, Y.-L.; Ratan, R. R.; Holson, E. B. “Hydroxamate-based Histone Deacetylase Inhibitors Can Protect Neurons from Oxidative Stress by Forming Catalase Mimetic Complexes with Intracellular Iron” Cell Chem. Biol. (formerly Chem. Biol.) 2015, 22, 439-445. Link
Highlighted In Chemistry & Biology: Tackling Oxidative Stress by a Direct Route: A New Job for HDAC Inhibitors?
10. Olson, D. E., Udeshi, N.; Wolfson, N. A.; Pitcairn, C. A.; Sullivan, E. D.; Jaffe, J.; Svinkina, T.; Natoli, T.; Liu, X.; Paulk, J.; McCarren, P.; Wagner, F. F.; Barker, D.; Howe, E.; Lazzaro, F.; Gale, J. P.; Zhang, Y.-L.; Subramanian, A.; Fierke, C.; Carr, S.; Holson, E. B. “An Unbiased Approach to Identify Endogenous Substrates of “Histone” Deacetylase 8” ACS Chem. Bio. 2014, 9, 2210-2216. Link
9. Sleiman, S. F.; Olson, D. E.; Bourassa, M. W.; Karuppagounder, S. S.; Zhang, Y.-L.; Gale, J.; Wagner, F. F.; Basso, M.; Coppola, G.; Pinto, J. T.; Holson, E. B.; Ratan, R. R. “Hydroxamic Acid-based Histone Deacetylase (HDAC) Inhibitors Can Mediate Neuroprotection Independent of HDAC Inhibition” J. Neurosci. 2014, 34, 14328-14337. Link
8. Olson, D. E.; Su, J. Y.; Roberts, D. A.; Du Bois, J. “Vicinal Diamination of Alkenes under Rh-Catalysis” J. Am. Chem. Soc. 2014, 136, 13506-13509. Link
7. Olson, D. E.; Wagner, F. F.; Kaya, T.; Gale, J; Aidoud, N.; Davoine, E. L.; Lazzaro, F.; Weïwer, M.; Zhang, Y.-L.; Holson, E. B. “Discovery of the First Histone Deacetylase 6/8 Dual Inhibitors” J. Med. Chem. 2013, 56, 4816-4820. Link
6. Wagner F. F.; Olson D. E.; Gale J. P.; Kaya T.; Weïwer M.; Aidoud N.; Thomas M.; Davoine E. L.; Lemercier B. C.; Zhang Y.-L.; Holson E. B. “Potent and Selective Inhibition of Histone Deacetylase 6 (HDAC6) Does Not Require a Surface-binding Motif” J. Med. Chem. 2013, 56, 1772-1776. Link
5. Olson, D. E.; Roberts, D. A.; Du Bois, J. “Synthesis of Differentially-substituted 1,2-Diamines through Advances in C–H Amination Technology” Org. Lett. 2012, 14, 6174-6177. Link
4. Olson, D. E.; Maruniak, A.; Malhotra, S.; Trost, B. M.; Du Bois, J. “Synthesis and Reactivity of Unique Heterocyclic Structures en route to Substituted Diamines” Org. Lett. 2011, 13, 336-339. Link
3. Olson, D. E. “Electrophilic Amination of Organometallic Reagents: Recent Discoveries and Mechanistic Insights” Mini-Rev. Org. Chem. 2011, 8, 341-346. Link
2. Trost, B. M.; Malhotra, S.; Olson, D. E.; Maruniak, A.; Du Bois, J. “Asymmetric Synthesis of Diamine Derivatives via Sequential Palladium and Rhodium Catalysis” J. Am. Chem. Soc. 2009, 131, 4190-4191. Link
1. Olson, D. E.; Du Bois, J. “Catalytic C–H Amination for the Preparation of Substituted 1,2-Diamines” J. Am. Chem. Soc. 2008, 130, 11248-11249. Link
